Reception Harry Hughes of PC MMGN called the game «one of this year's most polished indie titles», praising its immersiveness and tasteful integration of multiple gaming genres.
Players control individual ships, with which they can earn money by defeating enemies and then buy new ship parts.
Proto Galaxy may be played on single-player or multiplayer mode, where players can team up either online or on a single system.
A party celebrating the game's launch was held on October 15, 2010 at Memorial University.
On February 25, 2011, Source Studio released Proto Defense, which enhanced the level editor and provided gamers with a new tower-defense-style level as downloadable content.